Fig. 10

Summary of the impact of treatment on OCT energy-linked biomarker. A Representative OCTs from superior outer retina (left). ELM, external limiting membrane; MCP, region measured to evaluate the Mitochondria Configuration of Photoreceptors; RPE, retinal pigment epithelium. Representative reflectivity profiles in the direction indcated by the green arrow, in superior retina (right). ELM-RPE region is indicated by the horizontal line, MCP/AR is shown in pink. All reflectivity profiles are scaled the same; no y-axis is shown because units are arbitrary. No signal intensity normalization was performed for these indices. MCP/AR values did not depend on side, and means did not differ between sides so average over side are presented. B and C Summary of quantitative light–dark changes in bioenergy OCT biomarkers in untreated (n = 9), DMSO treated (n = 4), and R-carvedilol (R–C; n = 5) 5xFAD B6J mice. Black horizontal line indicates P < 0.05 (two-tailed, linear mixed-model analysis; mean ± 95% confidence interval [CI]). Individual data points represent the measured value for each mouse