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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Longitudinal multiomics analysis of aggressive pituitary neuroendocrine tumors: comparing primary and recurrent tumors from the same patient, reveals genomic stability and heterogeneous transcriptomic profiles with alterations in metabolic pathways

Fig. 5

Panel A RT-qPCR validation of DGKG gene expression in corticotroph, somatotroph, lactotroph, thyrotroph, and gonadotroph PitNET from a second independent cohort. Panel B DGKG gene expression in a third independent cohort from E-MTAB-7768, confirming our transcriptome and RT-qPCR findings of DGKG gene expression. Panel C methylation specific PCR from the second cohort showing no differences in DNA methylation patterns, correlating with methylome analysis from recurrent tumors. Panel D immunofluorescence results from DGKG protein in somatotroph PitNET

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Acta Neuropathologica Communications

ISSN: 2051-5960

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