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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Hyperoside mitigates photoreceptor degeneration in part by targeting cGAS and suppressing DNA-induced microglial activation

Fig. 3

Post-light damage treatment of hyperoside improves the retinal function. Hyperoside (100 mg/kg) or 2-APB (10 mg/kg) was administered starting from 3 h post illumination and carried out twice a day for 7 d. ERG was recorded after the indicated treatments. (a) Representative scotopic ERG waves. (b) Amplitudes of a wave and b wave were plotted. Data were presented as mean ± SEM (n = 6 per group). *Compared to NLE, P < 0.05; **compared to NLE, P < 0.01; ***compared to NLE, P < 0.001; #compared to LE, P < 0.05; ##compared to LE, P < 0.01; ###compared to LE, P < 0.001. NLE, the vehicle-treated mice without the experimental light exposure; LE, the vehicle-treated light-exposed mice; HYP, the vehicle-treated light-exposed mice; 2-APB, the 2-APB-treated light-exposed mice

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