Fig. 2

Post-light damage treatment of hyperoside alleviates photoreceptor structural impairment. Hyperoside (100 mg/kg) or 2-APB (10 mg/kg) was administered starting from 3 h post illumination and carried out twice a day for 7 d. (a) Representative OCT scans of the superior and inferior retinas taken from day 7 post light exposure. (b) The ONL thickness measured at 250, 500, 750, and 1000 μm away from the ONH. Data were expressed as mean ± SEM (n = 6 per group). ^***Compared to NLE, P < 0.001; ^##compared to LE, P < 0.01, ^###compared to LE, P < 0.001. NLE, the vehicle-treated mice without light exposure; LE, the light-exposed mice treated with vehicle; HYP, the hyperoside-treated light-exposed mice; 2-APB, the 2-APB-treated light-exposed mice; INL, inner nuclear layer; IS, inner segment; ONH, optic nerve head; ONL, outer nuclear layer; OPL, outer plexiform layer; OS, outer segment