Fig. 11

A schematic drawing: Hyperoside may target DNA sensor cGAS and break the vicious cycle of microglial activation-instigated photoreceptor loss. Hyperoside directly interacts with cGAS, suppresses cGAS activation and lowers DNA-stimulated pro-inflammatory responses in microglia, which likely contribute to its effects at mitigating microglial activation-mediated neuroinflammation and photoreceptor degeneration. Dashed line box and dashed arrow indicate findings were derived from in vitro assays