Neuropeptide FF (NPFF)-positive nerve cells of the human cerebral cortex and white matter in controls, selected neurodegenerative diseases, and schizophrenia

Table 1 Stereological results for NPFF cell numbers in neocortical and allocortical gray and white matter of n = 9 control cases

NPFF / mm³		CG			FG			STG			M + ITG			ER			HF
		n	mean	SEM	n	mean	SEM	n	mean	SEM	n	mean	SEM	n	mean	SEM	n	mean	SEM
GM	Ctrl	9	29.68	0.6238	9	23.35	0.8447	9	18.16	0.7453	7	12.65	0.3570	6	19.12	0.7866	5	11.09	2.4057
	male	4	32.33	1.4677	4	21.59	0.7507	4	20.46	2.4056	3	11.94	0.3952	3	16.78	1.0049	3	11.44	4.8948
	female	5	27.02	0.8013	5	24.76	2.0322	5	16.31	0.6632	4	13.19	0.8162	3	21.45	1.8345	2	10.57	6.0536
WM	Ctrl	9	120.52	5.6536	9	86.09	2.8167	9	107.85	4.9794	7	59.24	1.2840	6	82.71	3.3912	5	48.47	7.7075
	male	4	158.59	9.4106	4	92.69	6.6393	4	108.50	16.5364	3	65.40	3.7503	3	74.93	8.8773	3	50.67	15.0151
	female	5	82.45	7.3605	5	80.82	5.2079	5	107.34	5.4204	4	54.62	0.8197	3	90.49	4.0013	2	45.18	21.4843
WM I-V	Ctrl	9	145.07	9.4573	9	140.95	4.7715	0	NE	–	7	65.16	2.6692	6	78.63	4.4234	0	NE	–
	male	4	207.63	17.2807	4	142.60	11.6020	0	NE	–	3	78.49	7.4024	3	84.44	13.1177	0	NE	–
	female	5	82.50	10.7189	5	139.64	9.0954	0	NE	–	4	55.15	1.9076	3	72.83	3.5157	0	NE	–
																			–
deep WM	Ctrl	9	74.65	3.6831	9	43.47	1.4738	0	NE	–	7	48.67	2.5019	4	93.94	13.8241	0	NE	–
	male	4	98.63	7.3027	4	52.10	3.7941	0	NE	–	3	45.41	3.8987	2	46.13	2.6208	0	NE	–
	female	5	50.68	3.3587	5	36.56	1.3413	0	NE	–	4	51.12	5.6105	2	141.75	0.8237	0	NE	–

Bold indicate values for overall control group (male + female)
Quantitatively determined number of all NPFF-positive cells on average of the control cases examined normalized to the calculated volume of the areal analyzed (NPFF/mm³) for the following regions: cingulate gyrus (CG), frontal gyrus (FG), superior temporal gyrus (STG), medial and inferior temporal gyrus (M + ITG), entorhinal region (ER), and hippocampal formation (HF). Inclusive separation for males and females (male, female), number of cases analyzed (n), average of the determined number of NPFF-positive cells in the region analyzed (mean), control (Ctrl), gray matter (GM), white matter (WM), white matter compartments I-V (WM I-V), deep white matter (deep WM), standard deviation of mean (SEM), not evaluated (NE), SEM not calculable (–)

ISSN: 2051-5960