Fig. 5
NPFF-immunopositive cells/mm3 in the neocortex of n = 9 control cases versus n = 22 patients with neurodegenerative disorders. a/e Cell counts in the gray/white matter of the cingulate gyrus (CG-GM, CG-WM). b/f Cell densities in the frontal gyrus (FG-GM, FG/WM), c/g superior temporal gyrus (STG-GM, STG-WM), and d/h medial plus inferior temporal gyri (M + ITG-GM, M + ITG-WM). Males (black) and females (blue). For the demographics and neuropathological diagnoses of the n = 9 controls (5 females, 4 males), n = 8 sporadic ALS patients (2 females, 6 males), n = 8 AD patients (5 females, 3 males), n = 3 PiD patients (2 females, 1 male), and n = 3 schizophrenia patients (1 female, 2 males), see Supplementary Table 1. Quantification of NPFF-positive cells was normalized to the volume of analyzed surface area. Data are presented as mean ± SEM and analyzed by one-way ANOVA followed by Dunnett ‘s multiple comparisons test. Statistically significant differences are indicated (*p < 0.05; **p < 0.005; ***p < 0.001; ****p < 0.0001)