Fig. 3

NPFF-immunopositive cells/mm³ in the neocortical gray and white matter of n = 9 control cases. a. Cell counts in the gray matter of the cingulate gyrus (CG), frontal gyrus (FG), superior temporal gyrus (STG), and medial plus inferior temporal gyri (M + ITG) in 4 males (black) and 5 females (blue). See also Supplementary Table 1. b. Cell counts in the white matter of the same regions and individuals as in a. c. Cell counts in 4 males (black) and 5 females (blue) in the gray matter (GM), white matter (WM), white matter compartments I-V (WM I-V), and deep white matter (deep WM) of the cingulate gyrus. d. Cell counts in the gray matter (GM), white matter (WM), white matter compartments I–V (WM I-V), and deep white matter (deep WM) of the frontal gyrus. e. Cell counts in the gray matter (GM), white matter (WM), white matter compartments I-V (WM I-V), and deep white matter (deep WM) of the medial and inferior gyri. f. Cell counts in the gray matter (GM), white matter (WM), white matter compartments I-V (WM I-V), and deep white matter (deep WM) of the superior temporal gyrus. Quantification of NPFF-positive cells was normalized to the volume of analyzed surface area. Data are presented as mean ± SEM and analyzed by one-way ANOVA followed by Dunnett’s multiple comparisons test. Statistically significant differences are indicated (****p < 0.0001)