A longer time to relapse is associated with a larger increase in differences between paired primary and recurrent IDH wild-type glioblastomas at both the transcriptomic and genomic levels

Table 1 Univariate and multivariate Cox regression analyses of the risk score based on the constructed prognostic model and the two clinical features: MGMT methylation status and extent of resection

¹For the variables of risk score, MGMT methylation status, and extent of resection, “low risk score”, “methylated”, and “total” were used as the references, respectively
²For risk score, 87 cases were examined (43 with a low-risk score and 44 with a high-risk score). Regarding the availability of the examined clinical features, 49 (22 with a methylated status and 27 with a unmethylated status) and 41 (22 with a total resection and 19 with a subtotal resection) cases were used for assessing the importance of the MGMT methylation status and the extent of resection in the univariate analysis, respectively. HR, Hazard ratio
³With having overlapping gene expression data and the two clinical features, 22 cases were examined in the multivariate analysis

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