Fig. 5

Ontological analysis of the proteins up and down regulated in CFZS patients (A) Ontological associations between 63 proteins downregulated in CFZS (blue) and 34 proteins upregulated in CFZS patients (red) were established using Metascape and visualised using Cytoscape [37, 40] Grey lines indicate a direct interaction, circle size is determined by enrichment and circle colour is determined by p value. Up and downregulated networks were created separately with identical enrichment and p value scaling parameters. For graphical representation both up and down-regulated protein networks were scaled to match based on the enrichment key. (B) For each experimental group the two clusters with the highest Log p in cluster are documented in the table which outlines the enrichment, p value and proteins present within the cluster. All full list of all clusters and proteins present is available in Supplementary Table 2. (C) Proteomaps were generated using Log2 transformed protein abundance values of proteins which displayed a significant difference (p < 0.05) [22]