Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection

Rombaut, Anne; Jovancevic, Danica; Wong, Raymond Ching-Bong; Nicol, Alan; Brautaset, Rune; Finkelstein, David I.; Nguyen, Christine T. O.; Tribble, James R.; Williams, Pete A.

doi:10.1186/s40478-024-01782-3

Table 2 P value and 95% CI per comparison of conditions in the TH+ cell analysis

From: Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection

TH+ cell analysis	P value	95% CI
Cell soma count
Naïve control—vehicle control	0.600	[− 1.738, 0.555]
Naïve control—MPTP 5 mg/ml 7 days after injection	0.853	[− 1.760, 0.794]
Naïve control—MPTP 5 mg/ml 14 days after injection	1.000	[− 1.421, 1.244]
Naïve control—MPTP 5 mg/ml 21 days after injection	0.777	[− 1.819, 0.735]
Naïve control—MPTP 50 mg/ml 7 days after injection	0.031 *	[− 2.647, − 0.092]
Naïve control—MPTP 50 mg/ml 14 days after injection	0.998	[− 1.639, 1.174]
Naïve control—MPTP 50 mg/ml 21 days after injection	0.997	[− 1.658, 1.155]
Dendrite length
Naïve control—vehicle control	0.680	–
Naïve control—MPTP 5 mg/ml 7 days after injection	0.710	–
Naïve control—MPTP 5 mg/ml 14 days after injection	0.710	–
Naïve control—MPTP 5 mg/ml 21 days after injection	0.980	–
Naïve control—MPTP 50 mg/ml 7 days after injection	0.710	–
Naïve control—MPTP 50 mg/ml 14 days after injection	0.760	–
Naïve control—MPTP 50 mg/ml 21 days after injection	1.000	–
Dendrite volume
Naïve control—vehicle control	0.640	–
Naïve control—MPTP 5 mg/ml 7 days after injection	0.890	–
Naïve control—MPTP 5 mg/ml 14 days after injection	0.640	–
Naïve control—MPTP 5 mg/ml 21 days after injection	0.960	–
Naïve control—MPTP 50 mg/ml 7 days after injection	0.780	–
Naïve control—MPTP 50 mg/ml 14 days after injection	0.890	–
Naïve control—MPTP 50 mg/ml 21 days after injection	0.960	–
Varicosities count
Naïve control—vehicle control	0.700	–
Naïve control—MPTP 5 mg/ml 7 days after injection	0.700	–
Naïve control—MPTP 5 mg/ml 14 days after injection	0.700	–
Naïve control—MPTP 5 mg/ml 21 days after injection	0.970	–
Naïve control—MPTP 50 mg/ml 7 days after injection	0.700	–
Naïve control—MPTP 50 mg/ml 14 days after injection	0.930	–
Naïve control—MPTP 50 mg/ml 21 days after injection	0.970	–
Varicosities volume
Naïve control—vehicle control	0.289	[− 4131.158, 21,778.773]
Naïve control—MPTP 5 mg/ml 7 days after injection	1.000	[− 13670.351, 13,124.131]
Naïve control—MPTP 5 mg/ml 14 days after injection	0.839	[− 19863.108, 9225.526]
Naïve control—MPTP 5 mg/ml 21 days after injection	0.983	[− 10919.090, 17,209.257]
Naïve control—MPTP 50 mg/ml 7 days after injection	1.000	[− 14200.632, 13,927.715]
Naïve control—MPTP 50 mg/ml 14 days after injection	0.759	[− 9469.938, 22,755.132]
Naïve control—MPTP 50 mg/ml 21 days after injection	0.920	[− 10529.049, 19,853.038]

Significance: *P < 0.05, **P < 0.01, ***P < 0.001

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ISSN: 2051-5960

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