Fig. 5

Nicotinamide provides a robust, long-term retinal ganglion cell neuroprotection following intravitreal MPTP administration. A Retinal ganglion cells were labelled in whole-mounted retina with anti-RBPMS (magenta) in Thy1-CFP mice. B There was no significant difference in RBPMS+ retinal ganglion cell density between the vehicle control group and the groups treated with NAM prior to injection of 5 mg/mL MPTP or 50 mg/mL MPTP, supporting the protection of retinal ganglion cells by NAM. Scale bar = 20 µm in A