Table 2 Severity scores of cerebrovascular and Lewy-related neuropathologies in select brain areas by ethnic group (n = 276)

Arteriolosclerosis (0–3: 0 = None, 1 = Mild, 2 = Moderate, 3 = Severe) [9, 15]

Temporal lobe, median (min, q3, max)

2 (0,2,3)

2 (0,2,3)

0.60

total

163

79

Parietal lobe, median (min, q3, max)

total

2 (0,2,3)

177

1 (0,2,3)

87

0.39

Frontal lobe, median (min, q3, max)

total

1 (0,2,3)

170

2 (0,2,3)

85

0.27

CAA Density (0–3: 0 = None, 1 = Mild, 2 = Moderate, 3 = Severe) [32]

Temporal lobe, median (min, q3, max)

1 (0,2,3)

1 (0,3,3)

0.17

total

171

82

Parietal lobe, median (min, q3, max)

total

1 (0,2,3)

164

2 (0,3,3)

82

0.11

Posterior Hippocampus, median (min, q3, max)

1 (0,1,3)

1 (0,2,3)

0.01

total

166

83

Frontal lobe, median (min, q3, max)

total

1 (0,2,3)

165

2 (0,3,3)

85

0.28

Cerebellum, median (min, q3, max)

total

1 (0,3,3)

181

2 (0,3,3)

84

0.01

CAA Vonsattel (0–4: Grade 0 ~ 4) [33]

Temporal lobe, median (min, q3, max)

2 (0,3,4)

2 (0,3,4)

0.35

total

171

82

Parietal lobe, median (min, q3, max)

total

2 (0,3,4)

163

2 (0,4,4)

82

0.14

Posterior Hippocampus, median (min, q3, max)

1 (0,2,4)

1 (0,3,4)

0.08

total

166

83

Frontal lobe, median (min, q3, max)

total

2 (0,3,4)

166

2 (0,3,4)

85

0.32

Cerebellum, median (min, q3, max)

total

2 (0,2,4)

181

2 (0,3,4)

84

0.04

LBs/LNs (0–4: 0 = Absent, 1 = Mild, 2 = Moderate, 3 = Severe, 4 = Very Severe) [22, 23]

Temporal cortex, median (min, q3, max)

0 (0,1,4)

0 (0,1,4)

0.03

total

178

82

Amygdala, median (min, q3, max)

0 (0,2,4)

0 (0,4,4)

0.11

total

165

79

Substantia nigra, median (min, q3, max)

0 (0,1,4)

0 (0,1,4)

0.09

total

180

81

Frontal cortex, median (min, q3, max)

0 (0,0,3)

0 (0,1,3)

0.01

total

172

84

Locus coeruleus, median (min, q3, max)

0 (0,1,4)

0 (0,1,4)

0.33

total

165

79