Fig. 1

Severity of cerebral amyloid angiopathy (CAA) and arteriolosclerosis (ART) in select neuroanatomic regions. a Examples of cerebral amyloid angiopathy density (CAAD) in frontal, parietal, and temporal lobes, posterior hippocampus (PHIPPO), and cerebellum; overall regional density scores are listed in panel within each image. Cases were selected based on heritage group and center, having similar age at death, sex, and AD likelihood (ADNC = Alzheimer’s disease neuropathologic changes). Scale bar = 500 μm. b Violin plots of the severity of ART, CAAD, and cerebral amyloid angiopathy Vonsattel score (CAAV) in select brain areas between Hispanic and non-Hispanic White decedents. CAAD and CAAV were assessed in five areas: frontal, parietal, and temporal lobes, posterior hippocampus (figure represents collateral sulcus), and cerebellum. ART was assessed in the frontal, parietal, and temporal white matter. The violin plots indicated the distribution of the data while the boxes showed the first and third quartiles, median, and range