Fig. 4

Quantification of Ferritin positive cells showed the highest amount of microglia dystrophy in cases with ADNC. a Overview of ferritin pos. microglia in HPC, FC, OCC and SN of control and disease cases. Quantification of ferritin pos. cells in hippocampus (b), frontal cortex (c), occipital cortex (d) and substantia nigra (e). HPC data points contain hippocampal subregions (CA4-1, subiculum, entorhinal cortex, see Supp. Figure 5), OCC contains data points from subregions (striate cortex and peristriate cortex). Red – female, blue – male. No sex differences could be shown across the examined brain regions. One-way ANOVA with Tukey's multiple comparisons test was used for statistical analysis. *p < 0.05, **p < 0.01, ***p < 0.001. Scale bar = 60 μm