Fig. 4

CNV plots of a Glioblastoma, IDH wildtype (CNS WHO grade 4), subtype RTK II. Note the ‘gain 7 / LOH 10’ signature and additional chromosomal alterations that can be appreciated from both the nanopore (A) and the corresponding microarray plots (B). Circumscribed alterations such as the EGFR gene amplification and complete CDKN2A/B deletion are frequently missed in the nanopore data, precluding meaningful single gene annotations in low-coverage sequencing-based copy number plots