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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Human adipose tissue-derived stem cell extracellular vesicles attenuate ocular hypertension-induced retinal ganglion cell damage by inhibiting microglia- TLR4/MAPK/NF-κB proinflammatory cascade signaling

Fig. 6

ADSC-EVs reduce microglial activation and microglia-derived neuroinflammatory response chemokines in the retina and optic nerve of OHT mice 2 weeks after injection. (A) Representative retinal immunostaining and quantification of the expression of CCL2 and Iba-1 (n = 5, **p < 0.01, ***p < 0.001). (B) Representative retina immunostaining and quantification of the expression of CD68 and Iba-1 (n = 6, *p < 0.05, ***p < 0.001). (C) Representative optic nerve immunostaining and quantification of the expression of CD68 and Iba-1 (n = 5, **p < 0.01, ***p < 0.001). (D) Representative optic nerve immunostaining and quantification of the expression of CCL2 and Iba-1 (n = 5, *p < 0.05, ***p < 0.001)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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