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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: A rare non-gadolinium enhancing sarcoma brain metastasis with microenvironment dominated by tumor-associated macrophages

Fig. 2

Histopathologic findings in the midbrain at autopsy. (A) Lesion contains MUC4 + sarcoma cells. (B) Extensive infiltration of CD68 + and CD163 + TAMs, with highest density at the leading edge of the metastasis corresponding to diffusion restriction on MRI (red arrows). (C) High magnification images of lesion depict morphology of CD68 + TAMs. Scale bar = 100 μm. (D) Immunohistochemical staining within the boxed region at left reveals a paucity of CD3 + T cells and CD20 + B cells compared to abundant CD163 + TAMs. Scale bar = 250 μm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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