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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits

Fig. 8

GPC6 mRNA is significantly increased in neuronal nuclei containing TDP-43 associated cryptic exons compared to normal nuclei within FTD patient brains. GPC6 mRNA levels as shown, in nuclei in which TDP-43 associated cryptic exons (e.g., STMN2, KALRN) have been identified (N = 87 neurons) compared to nuclei containing canonical splice junctions (N = 377 neurons). P = 0.015. a.u. arbitrary units

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Acta Neuropathologica Communications

ISSN: 2051-5960

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