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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysis

Fig. 4

Regulatory network highlights NFATC4 as the hub regulator for rGBM-emerged cell subpopulation. A t-SNE plot colored by subgroups classified by P and GS signatures. B t-SNE showing the expression of genes from P and GS signatures. C t-SNE plot showing the expression scores for mitotic, S phase, and GS signatures. D Stacked bar plot showing the proportional composition of P and GS subgroups. E t-SNE showing subpopulations characterized by anatomic features profiled by Ivy GAP. F t-SNE plot showing the expression of genes from Ivy anatomic features. G t-SNE plot showing the expression scores for Ivy anatomic features. H Stacked bar plot showing the proportional composition of subgroups assigned by Ivy anatomic features. I t-SNE plot showing the expression scores of signatures from CancerSEA. J Heatmap showing the TFs for each GBM cell subpopulation deduced from the DEG list. K TF regulatory network showing the predicted candidate TFs and target genes in C7

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Acta Neuropathologica Communications

ISSN: 2051-5960

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