Fig. 3

a Principal component analysis of Group 3/4 MB gene expression primary-relapse dataset based on top 500 most highly variable genes, target component variance percentage (VP) is shown in axis labels. Primary and relapse tumor profiles from the same patient are connected via dot lines. b Association of transcriptome variance between primary and relapse Group 3/4 MB with age of the patients. c Boxplot demonstrating the transcriptome variance between primary and relapse Group 3/4 MB among relapse patterns (metastases: 11, combined: 9 cases). d Heatmap of top most confident genes differentially expressed between primary and relapse Group 3/4 MB, either down-regulated (first block, n = 20) or up-regulated (second block, n = 20) in relapses respectively. e, f Boxplots of differentially expressed genes either up-regulated (e, PDIA6) or down-regulated (f, SNORD115-23) in Group 3/4 MB relapses vs primaries