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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Immune cell gene expression signatures in diffuse glioma are associated with IDH mutation status, patient outcome and malignant cell state, and highlight the importance of specific cell subsets in glioma biology

Fig. 6

Immunotherapy-treated glioma datasets. A Stacked bar plots representing relative proportion of 10 broader category of immune cell types from LM10 across samples treated with checkpoint inhibitor. B Stacked bar plots representing the relative proportions of 4 malignant cell-states across all immunotherapy treated samples. C Forest plot representing the association between their dichotomous immune cell fractions and their overall survival. D Monocyte-based gene expression clusters represented by tSNE followed by E Kaplan–Meier curves denoting distinct survival between the two clusters. F Boxplots depicting differential distribution of epithelial-mesenchymal transition markers between the two immune-based survival groups derived from monocytes from samples treated with checkpoint inhibitor. G Scatter plots representing significant positive correlations between the epithelial-mesenchymal transition and the T cell exhaustion scores both in patients treated with a checkpoint inhibitor, as well as larger cohorts. H Forest plot representing the insignificant or inconsistent association between their dichotomous monocytic fractions in non-immunotherapy or non-checkpoint inhibitor treated IDH-WT tumors (from TCGA, CGGA325 and CGGA693) and their overall survival

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Acta Neuropathologica Communications

ISSN: 2051-5960

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