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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation

Fig. 3

Molecular chaperones are sequestered by cytoplasmic poly-GA aggregates. A Co-expression of mCherry-tagged poly-GA and EGFP-tagged chaperones and adapter proteins shows the tight association of SQSTM1, UBXN6, VCP, and HSPA8 within the periphery of dense cytoplasmic poly-GA aggregates. B Endogenous BAG3, SQSTM1, UBXN6, VCP, and HSPA8 proteins are sequestered around EGFP-tagged poly-GA aggregates, disrupting their normal endogenous staining pattern. Scale bar: 5 µm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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